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› 8pji

X-ray diffraction
1.7Å resolution

MLLT1 in complex with compound 10a

Released:
DOI: 10.2210/pdb8pji/pdb
Model geometry
Fit model/data
PDB entry 8pji coloured by chain, front view.
PDB entry 8pji coloured by chain, side view.
PDB entry 8pji coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Raux B, Buchan KA, Bennett J, Christott T, Dowling MS, Farnie G, Fedorov O, Gamble V, Gileadi C, Giroud C, Huber KVM, Korczynska M, Limberakis C, Narayanan A, Owen DR, Sáez LD, Stock IA, Londregan AT
Bioorg Med Chem Lett 129546 (2023)
PMID: 37944866

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein ENL Chain: A
Molecule details ›
Chain: A
Length: 154 amino acids
Theoretical weight: 18.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03111 (Residues: 1-148; Coverage: 27%)
Gene names: ENL, LTG19, MLLT1, YEATS1
Sequence domains: YEATS family

Ligands and Environments

4 bound ligands:
Ligand EDO 2 x EDO
Ligand DMS 1 x DMS
Ligand ZJF 1 x ZJF
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P43212
Unit cell:
a: 49.532Å b: 49.532Å c: 132.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.243 0.277
Expression system: Escherichia coli

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