Function and Biology Details
Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-270676 (preferred)
Entry contents:
2 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (4 distinct):
Histone deacetylase 5
Molecule details ›
Chain: X
Length: 18 amino acids
Theoretical weight: 2.08 KDa
Source organism: Homo sapiens
Expression system: synthetic construct
UniProt:
Length: 18 amino acids
Theoretical weight: 2.08 KDa
Source organism: Homo sapiens
Expression system: synthetic construct
UniProt:
- Canonical:
Q9UQL6 (Residues: 179-195; Coverage: 2%)
MADS-box domain-containing protein
Molecule details ›
Chains: A, B
Length: 95 amino acids
Theoretical weight: 11.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: SRF-type transcription factor (DNA-binding and dimerisation domain)
Length: 95 amino acids
Theoretical weight: 11.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: Q05BX2 (Residues: 1-95; Coverage: 68%)
Sequence domains: SRF-type transcription factor (DNA-binding and dimerisation domain)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
ESRF BEAMLINE ID23-2
Spacegroup:
P212121
Expression systems:
- synthetic construct
- Escherichia coli BL21(DE3)
