Function and Biology Details
Reactions catalysed:
ATP + H(2)O = ADP + phosphate
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero pentadecamer (preferred)
PDBe Complex ID:
PDB-CPX-301367 (preferred)
Entry contents:
12 distinct polypeptide molecules
3 distinct RNA molecules
3 distinct RNA molecules
Macromolecules (15 distinct):
Splicing factor 3A subunit 1
Molecule details ›
Chain: 7
Length: 793 amino acids
Theoretical weight: 88.99 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 793 amino acids
Theoretical weight: 88.99 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
Q15459 (Residues: 1-793; Coverage: 100%)
Sequence domains:
Probable ATP-dependent RNA helicase DDX23
Molecule details ›
Chain: G
Length: 820 amino acids
Theoretical weight: 95.79 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 820 amino acids
Theoretical weight: 95.79 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: Q9BUQ8 (Residues: 1-820; Coverage: 100%)
Sequence domains:
U4/U6.U5 tri-snRNP-associated protein 1
116 kDa U5 small nuclear ribonucleoprotein component
Ubiquitin carboxyl-terminal hydrolase 39
Pre-mRNA-processing-splicing factor 8
RNA-binding protein 42
Pre-mRNA-processing factor 6
U4/U6 small nuclear ribonucleoprotein Prp31
U4/U6 small nuclear ribonucleoprotein Prp3
Thioredoxin-like protein 4A
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
