› 8qwz

X-ray diffraction
2.6Å resolution

Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with 4-(6-(6-isopropoxy-1H-indol-1-yl)pyrazin-2-yl)benzoic acid

Released:
DOI: 10.2210/pdb8qwz/pdb
Model geometry
Fit model/data
PDB entry 8qwz coloured by chain, front view.
PDB entry 8qwz coloured by chain, side view.
PDB entry 8qwz coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kraemer A, Galal K, Willson T, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 338 amino acids
Theoretical weight: 40.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-337; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand SO4 11 x SO4
Ligand X5E 2 x X5E
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P43212
Unit cell:
a: 127.842Å b: 127.842Å c: 125.341Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.245
Expression system: Escherichia coli

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