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› 8riy

X-ray diffraction
2.29Å resolution

Function and Biology Details

Reactions catalysed: 
D-ribose 5-phosphate + ATP + H(+) = ADP-D-ribose + diphosphate.
ADP-D-ribose + H2O = D-ribose 5-phosphate + AMP + 2 H(+).
(1) 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193850 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-sugar pyrophosphatase Chains: AAA, BBB
Molecule details ›
Chains: AAA, BBB
Length: 209 amino acids
Theoretical weight: 23.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKK9 (Residues: 1-208; Coverage: 95%)
Gene names: HSPC115, NUDIX5, NUDT5
Sequence domains: NUDIX domain

Ligands and Environments

1 bound ligand:
Ligand W0O 2 x W0O
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P6122
Unit cell:
a: 60.605Å b: 60.605Å c: 502.608Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.229 0.226 0.295
Expression system: Escherichia coli

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