› 8s5k

Electron Microscopy
3.8Å resolution

Full-length human cystathionine beta-synthase, basal state, single particle reconstruction

Released:
DOI: 10.2210/pdb8s5k/pdb
PDB entry 8s5k coloured by chain, front view.
PDB entry 8s5k coloured by chain, side view.
PDB entry 8s5k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Architecture and regulation of filamentous human cystathionine beta-synthase.
McCorvie TJ, Adamoski D, Machado RAC, Tang J, Bailey HJ, Ferreira DSM, Strain-Damerell C, Baslé A, Ambrosio ALB, Dias SMG, Yue WW
OpenAccess logo Nat Commun 15 2931 (2024)
PMID: 38575566
Related structures: EMD-19738

Function and Biology Details

Reaction catalysed: 
L-serine + L-homocysteine = L-cystathionine + H(2)O
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-243162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cystathionine beta-synthase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 552 amino acids
Theoretical weight: 60.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35520 (Residues: 1-551; Coverage: 100%)
Gene name: CBS
Sequence domains:

Ligands and Environments


Cofactor: Ligand HEM 8 x HEM
No bound ligands
1 modified residue:
Ligand LLP 8 x LLP

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.8Å
Relevant EMDB volumes: EMD-19738
Expression system: Escherichia coli

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