› 8s75

X-ray diffraction
1.42Å resolution

Soluble epoxide hydrolase in complex with PROTAC FL412

Released:
DOI: 10.2210/pdb8s75/pdb
Model geometry
Fit model/data
PDB entry 8s75 coloured by chain, front view.
PDB entry 8s75 coloured by chain, side view.
PDB entry 8s75 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kumar A, Schoenfeld J, Hiesinger K, Lillich F, Proschak E, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
(9S,10S)-10-hydroxy-9-(phosphonooxy)octadecanoate + H(2)O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate
An epoxide + H(2)O = a glycol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152744 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bifunctional epoxide hydrolase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 367 amino acids
Theoretical weight: 41.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P34913 (Residues: 198-198, 222-555; Coverage: 60%)
Gene name: EPHX2
Sequence domains: alpha/beta hydrolase fold

Ligands and Environments

3 bound ligands:
Ligand PG4 1 x PG4
Ligand EDO 7 x EDO
Ligand A1H5L 2 x A1H5L
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 47.125Å b: 80.182Å c: 89.417Å
α: 90° β: 91.54° γ: 90°
R-values:
R R work R free
0.189 0.187 0.22
Expression system: Escherichia coli

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