› 8sah

Electron Microscopy
3.2Å resolution

Huntingtin C-HEAT domain in complex with HAP40

Released:
DOI: 10.2210/pdb8sah/pdb
PDB entry 8sah coloured by chain, front view.
PDB entry 8sah coloured by chain, side view.
PDB entry 8sah coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.
Alteen MG, Deme JC, Alvarez CP, Loppnau P, Hutchinson A, Seitova A, Chandrasekaran R, Silva Ramos E, Secker C, Alqazzaz M, Wanker EE, Lea SM, Arrowsmith CH, Harding RJ
Structure (2023)
PMID: 37390814
Related structures: EMD-28766

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150024 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Huntingtin Chain: A
Molecule details ›
Chain: A
Length: 1057 amino acids
Theoretical weight: 117.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42858 (Residues: 2093-3136; Coverage: 33%)
Gene names: HD, HTT, IT15
Sequence domains: Huntingtin, C-terminal HEAT
40-kDa huntingtin-associated protein Chain: B
Molecule details ›
Chain: B
Length: 389 amino acids
Theoretical weight: 41.34 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23610 (Residues: 1-371; Coverage: 100%)
Gene names: F8A1, F8A2, F8A3

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-28766
Expression system: Spodoptera frugiperda

Quick links

Citations

1 mention without citation

Engineering the Active Site Lid Dynamics to Improve the Catalytic Efficiency of Yeast Cytosine Deaminase.
Deng et al. (2023)