› 8sb6

X-ray diffraction
1.8Å resolution

Structure of human BRD2-BD1 bound to a histone H4 acetyl-methyllysine peptide

Released:
DOI: 10.2210/pdb8sb6/pdb
Model geometry
Fit model/data
PDB entry 8sb6 coloured by chain, front view.
PDB entry 8sb6 coloured by chain, side view.
PDB entry 8sb6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Acetyl-methyllysine marks chromatin at active transcription start sites.
Lu-Culligan WJ, Connor LJ, Xie Y, Ekundayo BE, Rose BT, Machyna M, Pintado-Urbanc AP, Zimmer JT, Vock IW, Bhanu NV, King MC, Garcia BA, Bleichert F, Simon MD
Nature (2023)
PMID: 37731000

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
monomeric
Assembly name:
PDBe Complex ID:
PDB-CPX-273442 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bromodomain-containing protein 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 124 amino acids
Theoretical weight: 14.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25440 (Residues: 74-194; Coverage: 15%)
Gene names: BRD2, KIAA9001, RING3
Sequence domains: Bromodomain
Histone H4 Chains: D, E
Molecule details ›
Chains: D, E
Length: 15 amino acids
Theoretical weight: 1.4 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P62805 (Residues: 2-16; Coverage: 15%)
Gene names: H4-16, H4/A, H4/B, H4/C, H4/D, H4/E, H4/G, H4/H, H4/I, H4/J, H4/K, H4/M, H4/N, H4/O, H4C1, H4C11, H4C12, H4C13, H4C14, H4C15, H4C16, H4C2, H4C3, H4C4, H4C5, H4C6, H4C8, H4C9, H4F2, H4FA, H4FB, H4FC, H4FD, H4FE, H4FG, H4FH, H4FI, H4FJ, H4FK, H4FM, H4FN, H4FO, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4, HIST2H4A, HIST2H4B, HIST4H4

Ligands and Environments

No bound ligands
1 modified residue:
Ligand 7QK 4 x 7QK

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: OTHER
Spacegroup: C2
Unit cell:
a: 115.378Å b: 55.819Å c: 68.006Å
α: 90° β: 94.414° γ: 90°
R-values:
R R work R free
0.182 0.181 0.204
Expression systems:
  • Escherichia coli
  • Not provided

Quick links