Function and Biology Details
Reactions catalysed:
an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 =an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+).
quinine + reduced [NADPH--hemoprotein reductase] + O2 = 3-hydroxyquinine+ oxidized [NADPH--hemoprotein reductase] + H2O + H(+).
1,8-cineole + reduced [NADPH--hemoprotein reductase] + O2 = 2-exo-hydroxy-1,8-cineole + oxidized [NADPH--hemoprotein reductase] + H2O +H(+).
(1) albendazole + reduced [NADPH--hemoprotein reductase] + O2 =albendazole S-oxide + oxidized [NADPH--hemoprotein reductase] + H2O +H(+).
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Cytochrome P450 3A4 (preferred)
PDBe Complex ID:
PDB-CPX-140290 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 3A4
Molecule details ›
Chain: A
Length: 487 amino acids
Theoretical weight: 55.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Cytochrome P450
Length: 487 amino acids
Theoretical weight: 55.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P08684 (Residues: 21-503; Coverage: 96%)
Sequence domains: Cytochrome P450
