› 8sp8

Electron Microscopy
2.79Å resolution

Human TRP channel TRPV6 in cNW30 nanodiscs inhibited by tetrahydrocannabivarin (THCV)

Released:
DOI: 10.2210/pdb8sp8/pdb
PDB entry 8sp8 coloured by chain, front view.
PDB entry 8sp8 coloured by chain, side view.
PDB entry 8sp8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin.
Neuberger A, Trofimov YA, Yelshanskaya MV, Khau J, Nadezhdin KD, Khosrof LS, Krylov NA, Efremov RG, Sobolevsky AI
OpenAccess logo Nat Commun 14 4630 (2023)
PMID: 37532722
Related structures: EMD-40676

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 666 amino acids
Theoretical weight: 76.56 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9H1D0 (Residues: 41-706; Coverage: 87%)
Gene names: ECAC2, TRPV6
Sequence domains:

Ligands and Environments

5 bound ligands:
Ligand Y01 12 x Y01
Ligand POV 28 x POV
Ligand I8E 8 x I8E
Ligand CA 1 x CA
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.79Å
Relevant EMDB volumes: EMD-40676
Expression system: Homo sapiens

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Citations

1 review citation

Targeting Nrf2 Signaling Pathway in Cancer Prevention and Treatment: The Role of Cannabis Compounds.
Rybarczyk et al. (2023)
1 other article

1 mention without citation

Molecular pharmacology of the onco-TRP channel TRPV6.
Neuberger et al. (2023)