› 8srb

Electron Microscopy
2.82Å resolution

Cryo-EM structure of TRPM2 chanzyme in the presence of EDTA and ADP-ribose

Released:
DOI: 10.2210/pdb8srb/pdb
PDB entry 8srb coloured by chain, front view.
PDB entry 8srb coloured by chain, side view.
PDB entry 8srb coloured by chain, top view.
Source organism: Salpingoeca rosetta
Primary publication:
Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution.
Huang Y, Kumar S, Lee J, Lü W, Du J
Nat Struct Mol Biol (2024)
PMID: 38773335
Related structures: EMD-40725

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-271142 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nudix hydrolase domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1494 amino acids
Theoretical weight: 168.25 KDa
Source organism: Salpingoeca rosetta
Expression system: Homo sapiens
UniProt:
  • Canonical: F2UB89 (Residues: 1-1494; Coverage: 100%)
Gene name: PTSG_05449
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand APR 4 x APR
Ligand CLR 12 x CLR
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.82Å
Relevant EMDB volumes: EMD-40725
Expression system: Homo sapiens

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Citations

1 review citation

Thermosensitive TRPM2: The regulatory mechanisms of its temperature sensitivity and physiological functions.
Kashio M. (2025)
1 other article