PDB 8swb structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

Endonucleolytic cleavage to 5'-phosphomonoester.

Biochemical function:

RNA-DNA hybrid ribonuclease activity

Biological process:

not assigned

Cellular component:

not assigned

Sequence domains:

Structure analysis Details

Assembly composition:

hetero trimer (preferred)

Assembly name:

Ribonuclease H1 and RNA and DNA (preferred)

PDBe Complex ID:

PDB-CPX-270761 (preferred)

Entry contents:

1 distinct polypeptide molecule
1 distinct DNA molecule
1 distinct RNA molecule

Macromolecules (3 distinct):

Ribonuclease H1 Chain: A

Molecule details ›

Chain: A
Length: 149 amino acids
Theoretical weight: 16.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: O60930 (Residues: 137-285; Coverage: 52%)

Gene names: RNASEH1, RNH1
Sequence domains: RNase H

DNA (5'-R(*(OMC)P*(N7X)P*(T39)P*(C5L)P*(A2M))-D(P*(SC)P*(PST)P*(SC)P*AP*(SC)P*(SC)P*(RC)P*(AS)P*(SC)P*(PST))-R(P*(6OO)P*(RFJ)P*(6OO)P*(6OO)P*(6NW))-3') Chain: D

Molecule details ›

Chain: D
Length: 20 nucleotides
Theoretical weight: 6.62 KDa
Source organism: Homo sapiens
Expression system: Not provided

RNA (5'-R(*UP*GP*GP*CP*GP*AP*GP*UP*GP*GP*GP*UP*GP*AP*GP*UP*GP*AP*GP*G)-3') Chain: B