› 8tbw

X-ray diffraction
2.08Å resolution

Human Class I MHC HLA-A2 in complex with sorting nexin 24 (127-135) peptide KLSHQPVLL

Released:
DOI: 10.2210/pdb8tbw/pdb
Model geometry
Fit model/data
PDB entry 8tbw coloured by chain, front view.
PDB entry 8tbw coloured by chain, side view.
PDB entry 8tbw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Accurate modeling of peptide-MHC structures with AlphaFold.
Mikhaylov V, Brambley CA, Keller GLJ, Arbuiso AG, Weiss LI, Baker BM, Levine AJ
Structure (2023)
PMID: 38113889

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-268795 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chains: A, D
Molecule details ›
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A140T913 (Residues: 25-299; Coverage: 79%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Sorting nexin-24 Chains: C, F

Ligands and Environments

1 bound ligand:
Ligand NO3 2 x NO3
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2221
Unit cell:
a: 66.052Å b: 157.57Å c: 185.912Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.172 0.205
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins.
Agarwal et al. (2024)
5 other articles