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8tou

X-ray diffraction
3.1Å resolution

ACE2-peptide 2 complex crystal form 3

Released:
Model geometry
Fit model/data

Function and Biology Details

Reaction catalysed:
angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-239720 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Processed angiotensin-converting enzyme 2 Chain: A
Molecule details ›
Chain: A
Length: 625 amino acids
Theoretical weight: 72.59 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BYF1 (Residues: 18-614; Coverage: 76%)
Gene names: ACE2, UNQ868/PRO1885
Sequence domains: Angiotensin-converting enzyme
Cyclic peptide 2 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.73 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
3 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21212
Unit cell:
a: 89.802Å b: 196.263Å c: 52.507Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.211 0.243
Expression systems:
  • Homo sapiens
  • Not provided