› 8u3h

Electron Microscopy
3.67Å resolution

Structure of Fmoc-Leu-OH bound Sialin

Released:
DOI: 10.2210/pdb8u3h/pdb
PDB entry 8u3h coloured by chain, front view.
PDB entry 8u3h coloured by chain, side view.
PDB entry 8u3h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and inhibition of the human lysosomal transporter Sialin.
Schmiege P, Donnelly L, Elghobashi-Meinhardt N, Lee CH, Li X
Nat Commun 15 4386 (2024)
PMID: 38782953
Related structures: EMD-41862

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sialin Chain: A
Molecule details ›
Chain: A
Length: 503 amino acids
Theoretical weight: 55.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NRA2 (Residues: 2-495; Coverage: 100%)
Gene name: SLC17A5
Sequence domains: Major Facilitator Superfamily

Ligands and Environments

2 bound ligands:
Ligand VP1 1 x VP1
Ligand LEU 1 x LEU
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.67Å
Relevant EMDB volumes: EMD-41862
Expression system: Homo sapiens

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