› 8v3s

Electron Microscopy
3.6Å resolution

Structure of CCP5 class3

Released:
DOI: 10.2210/pdb8v3s/pdb
PDB entry 8v3s coloured by chain, front view.
PDB entry 8v3s coloured by chain, side view.
PDB entry 8v3s coloured by chain, top view.
Source organisms:
Primary publication:
Tubulin code eraser CCP5 binds branch glutamates by substrate deformation.
Chen J, Zehr EA, Gruschus JM, Szyk A, Liu Y, Tanner ME, Tjandra N, Roll-Mecak A
Nature (2024)
PMID: 39020174
Related structures: EMD-42952

Function and Biology Details

Reaction catalysed: 
Delta-2-[tubulin] + H(2)O = Delta-3-[tubulin] + L-glutamate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274383 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cytosolic carboxypeptidase-like protein 5 Chain: A
Molecule details ›
Chain: A
Length: 605 amino acids
Theoretical weight: 68.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NDL9 (Residues: 2-605; Coverage: 68%)
Gene names: AGBL5, CCP5
Sequence domains:
beta tubulin tail Chain: M
Molecule details ›
Chain: M
Length: 5 amino acids
Theoretical weight: 488 Da
Source organism: Sus scrofa

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand GLU 1 x GLU
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.6Å
Relevant EMDB volumes: EMD-42952
Expression system: Spodoptera frugiperda

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