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› 8v6k

Electron Microscopy
2.46Å resolution

Apo-state cryo-EM structure of human TRPV3 in cNW30 nanodiscs

Released:
DOI: 10.2210/pdb8v6k/pdb
PDB entry 8v6k coloured by chain, front view.
PDB entry 8v6k coloured by chain, side view.
PDB entry 8v6k coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site.
Nadezhdin KD, Neuberger A, Khosrof LS, Talyzina IA, Khau J, Yelshanskaya MV, Sobolevsky AI
Sci Adv 10 eadn2453 (2024)
PMID: 38691614
Related structures: EMD-42994

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 808 amino acids
Theoretical weight: 92.68 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8NET8 (Residues: 1-759, 760-790; Coverage: 100%)
Gene name: TRPV3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand POV 32 x POV
Ligand NA 4 x NA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.46Å
Relevant EMDB volumes: EMD-42994
Expression system: Homo sapiens

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Citations

1 citations in other articles

Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels.
Trofimov et al. (2024)