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› 8vic

Electron Microscopy
3.48Å resolution

AP-6 bound human TMEM175

Released:
DOI: 10.2210/pdb8vic/pdb
PDB entry 8vic coloured by chain, front view.
PDB entry 8vic coloured by chain, side view.
PDB entry 8vic coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of Selective Inhibitors for the Lysosomal Parkinson's Disease Channel TMEM175.
Oh S, Lee J, Choi HJ, Kim S, Sapuru V, Kim M, Hite RK
J Am Chem Soc 146 23230-23239 (2024)
PMID: 39116214
Related structures: EMD-43257

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endosomal/lysosomal proton channel TMEM175 Chains: A, B
Molecule details ›
Chains: A, B
Length: 504 amino acids
Theoretical weight: 55.67 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9BSA9 (Residues: 1-504; Coverage: 100%)
Gene name: TMEM175
Sequence domains: Endosomal/lysosomal potassium channel TMEM175

Ligands and Environments

1 bound ligand:
Ligand A1AA3 1 x A1AA3
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.48Å
Relevant EMDB volumes: EMD-43257
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Unraveling pH Regulation of TMEM175, an Endolysosomal Cation Channel With a Role in Parkinson's Disease.
Schulze et al. (2025)