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› 8vt6

X-ray diffraction
2.31Å resolution

A structural study of selectivity mechanisms for JNK3 and p38 alpha with indazole scaffold probing compounds

Released:
DOI: 10.2210/pdb8vt6/pdb
Model geometry
Fit model/data
PDB entry 8vt6 coloured by chain, front view.
PDB entry 8vt6 coloured by chain, side view.
PDB entry 8vt6 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Park H, Feng Y

Function and Biology Details

Reaction catalysed: 
(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 42.24 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 2-360; Coverage: 100%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain

Ligands and Environments

2 bound ligands:
Ligand BOG 2 x BOG
Ligand WHQ 1 x WHQ
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 66.18Å b: 70.44Å c: 77Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.161 0.216
Expression system: Escherichia coli

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