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Electron Microscopy
4.07Å resolution

Cryo-EM Structure of the BRAF WT monomer bound to PLX8394

Released:

Function and Biology Details

Reaction catalysed:
(1) L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+).
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-147195 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine/threonine-protein kinase B-raf Chain: A
Molecule details ›
Chain: A
Length: 767 amino acids
Theoretical weight: 84.77 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15056 (Residues: 1-766; Coverage: 100%)
Gene names: BRAF, BRAF1, RAFB1
Sequence domains:
14-3-3 protein zeta/delta Chains: B, C
Molecule details ›
Chains: B, C
Length: 245 amino acids
Theoretical weight: 27.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P63104 (Residues: 1-245; Coverage: 100%)
Gene name: YWHAZ
Sequence domains: 14-3-3 protein

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 4.07Å
Relevant EMDB volumes: EMD-43678
Expression system: Homo sapiens