› 8w4c

X-ray diffraction
2.68Å resolution

The sigma-1 receptor from Xenopus laevis in complex with progesterone by soaking

Released:
DOI: 10.2210/pdb8w4c/pdb
Model geometry
Fit model/data
PDB entry 8w4c coloured by chain, front view.
PDB entry 8w4c coloured by chain, side view.
PDB entry 8w4c coloured by chain, top view.
Source organism: Xenopus laevis
Primary publication:
Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.
Fu C, Xiao Y, Zhou X, Sun Z
OpenAccess logo Nat Commun 15 5619 (2024)
PMID: 38965213

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179508 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sigma non-opioid intracellular receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 233 amino acids
Theoretical weight: 25.72 KDa
Source organism: Xenopus laevis
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q6DCU6 (Residues: 1-221; Coverage: 100%)
Gene names: oprs1, sigmar1
Sequence domains: ERG2 and Sigma1 receptor like protein

Ligands and Environments

1 bound ligand:
Ligand STR 1 x STR
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: I432
Unit cell:
a: 161.226Å b: 161.226Å c: 161.226Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.239
Expression system: Komagataella pastoris

Quick links