› 8wdt

X-ray diffraction
3.34Å resolution

Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue)

Released:
DOI: 10.2210/pdb8wdt/pdb
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PDB entry 8wdt coloured by chain, front view.
PDB entry 8wdt coloured by chain, side view.
PDB entry 8wdt coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor.
Araya T, Matsuba Y, Suzuki H, Doura T, Nuemket N, Nango E, Yamamoto M, Im D, Asada H, Kiyonaka S, Iwata S
Biochem Biophys Res Commun 695 149393 (2023)
PMID: 38171234

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-273496 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Adenosine receptor A2a Chain: A
Molecule details ›
Chain: A
Length: 351 amino acids
Theoretical weight: 39.11 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29274 (Residues: 2-316; Coverage: 77%)
Gene names: ADORA2, ADORA2A
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Antibody Fab fragment light chain Chain: B
Molecule details ›
Chain: B
Length: 213 amino acids
Theoretical weight: 23.36 KDa
Source organism: Mus musculus
Antibody Fab fragment heavy chain Chain: C

Ligands and Environments

1 bound ligand:
Ligand WCH 1 x WCH
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: C2
Unit cell:
a: 372.64Å b: 52.52Å c: 63.4Å
α: 90° β: 94.79° γ: 90°
R-values:
R R work R free
0.219 0.214 0.266
Expression system: Spodoptera frugiperda

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