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› 8xo6

X-ray diffraction
1.46Å resolution

Crystal structure of measles virus fusion inhibitor MEK35GE complexed with F protein HR1 (HR1-42) (P21212 space group)

Released:
DOI: 10.2210/pdb8xo6/pdb
Model geometry
Fit model/data
PDB entry 8xo6 coloured by chain, front view.
PDB entry 8xo6 coloured by chain, side view.
PDB entry 8xo6 coloured by chain, top view.
Source organism: Measles virus strain Edmonston
Primary publication:
Elucidation of Postfusion Structures of the Measles Virus F Protein for the Structure-Based Design of Fusion Inhibitors.
Takahara A, Nakatsu T, Hirata K, Hayashi H, Kawaji K, Aoki K, Inuki S, Ohno H, Kato H, Kodama E, Oishi S
J Med Chem 68 3123-3133 (2025)
PMID: 39887040

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-283504 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fusion glycoprotein F1 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 44 amino acids
Theoretical weight: 4.63 KDa
Source organism: Measles virus strain Edmonston
Expression system: Not provided
UniProt:
  • Canonical: P69353 (Residues: 143-184; Coverage: 8%)
Gene name: F
Measles virus fusion inhibitor MEK35GE Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 37 amino acids
Theoretical weight: 4.11 KDa
Source organism: Measles virus strain Edmonston
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ZN 10 x ZN
Ligand ACT 4 x ACT
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL45XU
Spacegroup: P21212
Unit cell:
a: 56.049Å b: 59.768Å c: 63.674Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.176 0.208
Expression system: Not provided

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