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› 8xx6

Electron Microscopy
2.99Å resolution

Structure of CXCR2 bound to CXCL8 (CXCR2-CXCL8-Go Full map)

Released:
DOI: 10.2210/pdb8xx6/pdb
PDB entry 8xx6 coloured by chain, front view.
PDB entry 8xx6 coloured by chain, side view.
PDB entry 8xx6 coloured by chain, top view.
Source organisms:
Primary publication:
Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Saha S, Sano FK, Sharma S, Ganguly M, Mishra S, Dalal A, Akasaka H, Kobayashi TA, Zaidi N, Tiwari D, Roy N, Yadav MK, Banerjee N, Saha S, Mohapatra S, Itoh Y, Chevigné A, Banerjee R, Shihoya W, Nureki O, Shukla AK
Mol Cell 85 976-988.e9 (2025)
PMID: 39978339
Related structures: EMD-38747

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-283872 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
C-X-C chemokine receptor type 2 Chain: R
Molecule details ›
Chain: R
Length: 416 amino acids
Theoretical weight: 46.7 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P25025 (Residues: 2-360; Coverage: 100%)
Gene names: CXCR2, IL8RB
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Interleukin-8 Chains: D, E
Molecule details ›
Chains: D, E
Length: 79 amino acids
Theoretical weight: 9.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10145 (Residues: 21-99; Coverage: 100%)
Gene names: CXCL8, IL8
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Guanine nucleotide-binding protein G(o) subunit alpha Chain: A
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: G
Antibody fragment ScFv16 Chain: S

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.99Å
Relevant EMDB volumes: EMD-38747
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

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