We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 8zli

Electron Microscopy
3.4Å resolution

BTA-2-bound E46K alpha-synuclein fibrils

Released:
DOI: 10.2210/pdb8zli/pdb
PDB entry 8zli coloured by chain, front view.
PDB entry 8zli coloured by chain, side view.
PDB entry 8zli coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils.
Liu K, Tao Y, Zhao Q, Xia W, Li X, Zhang S, Yao Y, Xiang H, Han C, Tan L, Sun B, Li D, Li A, Liu C
Proc Natl Acad Sci U S A 121 e2321633121 (2024)
PMID: 39172784
Related structures: EMD-60226

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153502 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chains: A, B, C, D, E, F, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, I, J, K, L
Length: 55 amino acids
Theoretical weight: 5.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37840 (Residues: 45-99; Coverage: 39%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein

Ligands and Environments

1 bound ligand:
Ligand A1L13 10 x A1L13
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.4Å
Relevant EMDB volumes: EMD-60226
Expression system: Escherichia coli

Quick links