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› 8zlo

Electron Microscopy
3.1Å resolution

F0502B-bound E46K alpha-synuclein fibril

Released:
DOI: 10.2210/pdb8zlo/pdb
PDB entry 8zlo coloured by chain, front view.
PDB entry 8zlo coloured by chain, side view.
PDB entry 8zlo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Binding adaptability of chemical ligands to polymorphic α-synuclein amyloid fibrils.
Liu K, Tao Y, Zhao Q, Xia W, Li X, Zhang S, Yao Y, Xiang H, Han C, Tan L, Sun B, Li D, Li A, Liu C
Proc Natl Acad Sci U S A 121 e2321633121 (2024)
PMID: 39172784
Related structures: EMD-60231

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153504 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-synuclein Chains: A, B, C, D, E, F, G, H, I, J, O, T
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, O, T
Length: 55 amino acids
Theoretical weight: 5.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia
UniProt:
  • Canonical: P37840 (Residues: 45-99; Coverage: 39%)
Gene names: NACP, PARK1, SNCA
Sequence domains: Synuclein

Ligands and Environments

1 bound ligand:
Ligand 1KI 10 x 1KI
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.1Å
Relevant EMDB volumes: EMD-60231
Expression system: Escherichia

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