› 9c3e

Electron Microscopy
3.5Å resolution

TCR - CD3 complex bound to HLA

Released:
DOI: 10.2210/pdb9c3e/pdb
PDB entry 9c3e coloured by chain, front view.
PDB entry 9c3e coloured by chain, side view.
PDB entry 9c3e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex.
Notti RQ, Yi F, Heissel S, Bush MW, Molvi Z, Das P, Molina H, Klebanoff CA, Walz T
bioRxiv (2024)
PMID: 37662363
Related structures: EMD-45166

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
PDBe Complex ID:
PDB-CPX-281372 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (8 distinct):
T cell receptor alpha chain constant Chain: A
Molecule details ›
Chain: A
Length: 272 amino acids
Theoretical weight: 30.21 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01848 (Residues: 1-138; Coverage: 99%)
Gene names: TCRA, TRAC
Sequence domains: Domain of unknown function (DUF1968)
T cell receptor beta chain MC.7.G5 Chain: B
Molecule details ›
Chain: B
Length: 557 amino acids
Theoretical weight: 62.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTU4 (Residues: 1-315; Coverage: 99%)
Gene name: TRB
Sequence domains:
T-cell surface glycoprotein CD3 delta chain Chain: D
T-cell surface glycoprotein CD3 epsilon chain Chains: E, F
T-cell surface glycoprotein CD3 gamma chain Chain: G
T-cell surface glycoprotein CD3 zeta chain Chains: X, Y
Beta-2-microglobulin; Cancer/testis antigen 1; Ig-like domain-containing protein Chain: H

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
2 bound ligands:
Ligand NAG 8 x NAG
Ligand CLR 2 x CLR
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.5Å
Relevant EMDB volumes: EMD-45166
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Recent advances in understanding TCR signaling: a synaptic perspective.
Dustin ML. (2023)