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› 9ctf

Electron Microscopy
3.9Å resolution

SapNP Reconstituted Human ABCB1 bound to Taxol in presence of ATP

Released:
DOI: 10.2210/pdb9ctf/pdb
PDB entry 9ctf coloured by chain, front view.
PDB entry 9ctf coloured by chain, side view.
PDB entry 9ctf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into binding-site access and ligand recognition by human ABCB1.
Kurre D, Dang PX, Le LTM, Gadkari VV, Alam A
EMBO J (2025)
PMID: 39806099
Related structures: EMD-45904

Function and Biology Details

Reactions catalysed: 
[ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.]
[ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent translocase ABCB1 Chain: A
Molecule details ›
Chain: A
Length: 1280 amino acids
Theoretical weight: 141.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08183 (Residues: 1-1280; Coverage: 100%)
Gene names: ABCB1, MDR1, PGY1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand UPL 22 x UPL
Ligand ATP 1 x ATP
Ligand TA1 1 x TA1
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.9Å
Relevant EMDB volumes: EMD-45904
Expression system: Homo sapiens

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