› 9f1l

X-ray diffraction
1.3Å resolution

First bromodomain of BRD4 in complex with ISOX-DUAL based degrader 35

Released:
DOI: 10.2210/pdb9f1l/pdb
Model geometry
Fit model/data
PDB entry 9f1l coloured by chain, front view.
PDB entry 9f1l coloured by chain, side view.
PDB entry 9f1l coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Balourdas DI, Edmonds AK, Marsh GP, Maple HJ, Spencer J, Knapp S, Joerger AC, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand EDO 4 x EDO
Ligand A1H83 1 x A1H83
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 56.788Å b: 43.881Å c: 56.333Å
α: 90° β: 102.207° γ: 90°
R-values:
R R work R free
0.158 0.157 0.182
Expression system: Escherichia coli

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