› 9gcx

X-ray diffraction
3.52Å resolution

Crystal structure of bovine Cytochrome bc1 in complex with inhibitor F8

Released:
DOI: 10.2210/pdb9gcx/pdb
Model geometry
Fit model/data
PDB entry 9gcx coloured by chain, front view.
PDB entry 9gcx coloured by chain, side view.
PDB entry 9gcx coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Novel antimalarial 3-substituted quinolones isosteres with improved pharmacokinetic properties.
Ge S, Jian R, Xuan Q, Zhu Y, Ren X, Li W, Chen X, Huang RK, Lee CS, Leung SC, Basilico N, Parapini S, Taramelli D, Pinthong N, Antonyuk SV, O'Neill PM, Sheng Z, Hong WD
Eur J Med Chem 284 117228 (2024)
PMID: 39752821

Function and Biology Details

Reaction catalysed: 
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 22-mer (preferred)
PDBe Complex ID:
PDB-CPX-132264 (preferred)
Entry contents:
10 distinct polypeptide molecules
Macromolecules (10 distinct):
Cytochrome b-c1 complex subunit 1, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 480 amino acids
Theoretical weight: 52.8 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P31800 (Residues: 1-480; Coverage: 100%)
Gene name: UQCRC1
Sequence domains:
Cytochrome b-c1 complex subunit 2, mitochondrial Chain: B
Molecule details ›
Chain: B
Length: 453 amino acids
Theoretical weight: 48.2 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23004 (Residues: 1-453; Coverage: 100%)
Gene name: UQCRC2
Sequence domains:
Cytochrome b Chain: C
Cytochrome c1, heme protein, mitochondrial Chain: D
Cytochrome b-c1 complex subunit Rieske, mitochondrial Chains: E, I
Cytochrome b-c1 complex subunit 7 Chain: F
Cytochrome b-c1 complex subunit 8 Chain: G
Cytochrome b-c1 complex subunit 6, mitochondrial Chain: H
Cytochrome b-c1 complex subunit 9 Chain: J
Cytochrome b-c1 complex subunit 10 Chain: K

Ligands and Environments

9 bound ligands:
Ligand LOP 6 x LOP
Ligand CDL 3 x CDL
Ligand HEM 2 x HEM
Ligand A1IKG 1 x A1IKG
Ligand LMT 1 x LMT
Ligand HEC 1 x HEC
Ligand FES 1 x FES
Ligand PSC 1 x PSC
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: P6522
Unit cell:
a: 210.082Å b: 210.082Å c: 344.844Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.188 0.241

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