› 9ije

Electron Microscopy
2.34Å resolution

Epinephrine-activated human beta3 adrenergic receptor

Released:
DOI: 10.2210/pdb9ije/pdb
PDB entry 9ije coloured by chain, front view.
PDB entry 9ije coloured by chain, side view.
PDB entry 9ije coloured by chain, top view.
Source organisms:
Primary publication:
Molecular Mechanism of the β3AR Agonist Activity of a β-Blocker.
Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X
Chempluschem e202400288 (2024)
PMID: 39046191
Related structures: EMD-60629

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-272297 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 340 amino acids
Theoretical weight: 37.41 KDa
Source organism: Rattus norvegicus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P54311 (Residues: 2-340; Coverage: 100%)
Gene name: Gnb1
Sequence domains: WD domain, G-beta repeat
Camelid antibody VHH fragment Chain: N
Molecule details ›
Chain: N
Length: 128 amino acids
Theoretical weight: 13.89 KDa
Source organism: Lama glama
Expression system: Escherichia coli
Single-chain Fv16 Chain: D
Beta-3 adrenergic receptor Chain: R
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Chain: A
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C

Ligands and Environments

1 bound ligand:
Ligand ALE 1 x ALE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.34Å
Relevant EMDB volumes: EMD-60629
Expression systems:
  • Trichoplusia ni
  • Escherichia coli
  • Homo sapiens

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