› 9ium

Electron Microscopy
3.08Å resolution

The structure of Candida albicans Cdr1 in milbemycin oxime-inhibited state

Released:
DOI: 10.2210/pdb9ium/pdb
PDB entry 9ium coloured by chain, front view.
PDB entry 9ium coloured by chain, side view.
PDB entry 9ium coloured by chain, top view.
Source organism: Candida albicans SC5314
Primary publication:
Cryo-EM structures of Candida albicans Cdr1 reveal azole-substrate recognition and inhibitor blocking mechanisms.
Peng Y, Lu Y, Sun H, Ma J, Li X, Han X, Fang Z, Tan J, Qiu Y, Qu T, Yin M, Yan Z
Nat Commun 15 7722 (2024)
PMID: 39242571
Related structures: EMD-60910

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-274763 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pleiotropic ABC efflux transporter of multiple drugs CDR1 Chain: A
Molecule details ›
Chain: A
Length: 1501 amino acids
Theoretical weight: 170.16 KDa
Source organism: Candida albicans SC5314
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q5ANA3 (Residues: 1-1501; Coverage: 100%)
Gene names: CAALFM_C305220WA, CDR1, CaO19.13421, CaO19.6000
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand A1L26 1 x A1L26
Ligand A1L27 1 x A1L27
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.08Å
Relevant EMDB volumes: EMD-60910
Expression system: Saccharomyces cerevisiae

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