EMD-4591
Leishmania tarentolae proteasome 20S subunit apo structure
EMD-4591
Single-particle3.3 Å
Deposition: 01/02/2019
Map released: 17/04/2019
Last modified: 18/12/2019
Sample Organism:
Leishmania tarentolae
Sample: Proteasome 20S subunit
Fitted models: 6qm8
Deposition Authors: Goswami P, Rowland P
Sample: Proteasome 20S subunit
Fitted models: 6qm8
Deposition Authors: Goswami P, Rowland P
Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Wyllie S ,
Brand S ,
Thomas M,
De Rycker M ,
Chung CW,
Pena I,
Bingham RP,
Bueren-Calabuig JA,
Cantizani J,
Cebrian D,
Craggs PD ,
Ferguson L,
Goswami P,
Hobrath J,
Howe J,
Jeacock L,
Ko EJ ,
Korczynska J,
MacLean L,
Manthri S,
Martinez MS,
Mata-Cantero L,
Moniz S,
Nuhs A,
Osuna-Cabello M,
Pinto E,
Riley J,
Robinson S,
Rowland P,
Simeons FRC,
Shishikura Y,
Spinks D,
Stojanovski L,
Thomas J,
Thompson S,
Viayna Gaza E,
Wall RJ ,
Zuccotto F ,
Horn D ,
Ferguson MAJ,
Fairlamb AH ,
Fiandor JM,
Martin J,
Gray DW ,
Miles TJ,
Gilbert IH ,
Read KD,
Marco M ,
Wyatt PG
(2019) PNAS , 116 , 9318 - 9323
(2019) PNAS , 116 , 9318 - 9323